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This form forms a complex with CXCL12 to initiate leukocyte recruitment through CXCR4 interaction [49], while also activating the NF-B pathway through TLR2/4/9 to induce pro-inflammatory cytokine (IL-6, TNF-) secretion from monocytes

Could demand for surgeries, devices and health care decline

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doi: 10.1007/s00535-012-0634-8 87

This is based on the clinical trial design, which used fixed dosing across weight categories